1R1430 Evolution of transmenbrane topology by internal gene duplication
نویسندگان
چکیده
منابع مشابه
Transmembrane Protein Evolution by Internal Gene Duplication
Recent studies reveal that transmenbrane (TM) topology (the number of TM segments (TMSs), the TMS position and the orientation of TMS to the membrane lipid bilayer) evolves by internal gene duplication [1, 6]. A large number of TM proteins, such as Bacteriorhodopsin, Na/Ca exchanger and the major facilitator superfamily, have been recognized to have internal repeats that presumably has arisen f...
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By considering the recent finding that unequal crossing over and other molecular interactions are contributing to the evolution of multigene families, a model of the origin of repetitive genes was studied by Monte Carlo simulations. Starting from a single gene copy, how genetic systems evolve was examined under unequal crossing over, random drift and natural selection. Both beneficial and deter...
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The importance of gene duplication in supplying raw genetic material to biological evolution has been recognized since the 1930s. Recent genomic sequence data provide substantial evidence for the abundance of duplicated genes in all organisms surveyed. But how do newly duplicated genes survive and acquire novel functions, and what role does gene duplication play in the evolution of genomes and ...
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Lynch and Conery (1) presented one of the first serious efforts to study the evolutionary fate of gene duplication using genomic sequence data. Their analysis led to several interesting observations, particularly with respect to the rate of gene duplication in eukaryotic genomes and the subsequent halflife of duplicates. These two parameters are of particular importance in studying the evolutio...
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Evolution of multigene families by gene duplication and subsequent diversification is analyzed assuming a haploid model without interchromosomal crossing over. Chromosomes with more different genes are assumed to have higher fitness. Advantageous and deleterious mutations and duplication/deletion also affect the evolution, as in previous studies. In addition, negative selection on the total num...
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ژورنال
عنوان ژورنال: Seibutsu Butsuri
سال: 2002
ISSN: 0582-4052,1347-4219
DOI: 10.2142/biophys.42.s97_3